This RFP is focused on supporting donor-facing applications and underlying systems of giving that test and demonstrate bold, innovative applications of AI that strengthen and expand philanthropic giving. Desired outputs include generating practical evidence and examples to inform broader practice across the philanthropic sector. We are particularly interested in solutions that increase support for Global Health & Development (GH&D) including efforts that improve health, economic opportunity and human well-being in low- and middle-income countries. Within this field, we are especially interested in efforts that reduce preventable mortality, combat infectious diseases, and expand pathways out of extreme poverty.